Barcelona’s La Liga title hopes were hit as they followed up their famous Champions League win over Paris St-Germain with a defeat at struggling Deportivo La Coruna.
Luis Enrique made five changes from the side who beat PSG 6-1, with the injured Neymar ruled out.
Barca were below par, falling behind to a close-range Joselu finish.
Luis Suarez equalised seconds after the restart but an Alex Bergantinos header sealed Depor’s win.
It was the first game Barcelona have ever lost when Suarez has scored, following 67 wins and five draws.
Real Madrid went top by two points after beating Real Betis 2-1 later on Sunday.